Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Young birds ( weeks). Causes: Infectious bursal disease virus . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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Possibly single-cycle replication incompetent and nontransmissible vector vaccines will gain more importance to overcome the risk of reversion to virulence of classical attenuated vaccine strains. The structure of a birnavirus polymerase reveals a distinct active site topology.

Also, diarrhoea, anorexia, depression, ruffled feathers, especially in the region of the head and the neck are present. A non-canonical lon proteinase lacking the ATPase domain employs the ser-Lys catalytic dyad to exercise broad control over the life cycle of a double-stranded RNA virus.

Young chickens that are weeks age are the most susceptible to clinical disease. Genetic characteristics of infectious bursal disease viruses from four continents.

Infectious bursal disease

Use of a vectored vaccine against infectious bursal disease of chickens in the face of high-titred maternally derived antibody. Mortality rates vary with virulence of the strain ni, the challenge dose, previous immunity, presence of concurrent disease, as well as the flock’s ability to mount an effective immune response.

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INFECTIOUS BURSAL DISEASE (GUMBORO) – Diseases of Poultry – The Poultry Site

Sequence comparisons of the variable VP2 region of eight infectious bursal pooultry virus isolates. Javascript is currently disabled in your browser. Company No part of this site may be reproduced without permission.

First described in Europe about 10 years ago, this new form of the disease has rapidly spread all over the world, causing dramatic losses; after a decade, it still represents a considerable threat to the poultry industry.

Genetic distance estimation predicts that these viruses are one of the most genetically divergent Poyltry and showed the highest between-group variance and genetic distance from vvIBDVs.


The enhanced virulence of very virulent infectious bursal disease virus disesae partly determined by its B-segment. The incubation period is short and the first symptoms appear days after infection.

Infectious bursal disease virus. Based on geographic origin, phylogenetic analysis using either partial or complete VP2 nucleotide sequences clustered vvIBDV strains in one well-defined major monophyletic lineage.

Immunization of chickens with VP2 protein of infectious bursal disease virus expressed in Arabidopsis thaliana. However, there are no indications of vertical transmission. Molecular epidemiologic evidence of homologous recombination in infectious bursal disease viruses. Although their origin is still under investigation, vvIBDVs have spread all over the world in a very explosive but conserved manner.

Efficacy of inactivated infectious bursal disease IBD vaccines: Identification of infectious bursal disease virus quasispecies in commercial vaccines and field isolates of this double-stranded RNA virus. Expression of innate response genes during in vitro and in vivo IBDV infection When administered per os, IBDV can be detected at 8—12 hours post infection in intestinal mononuclear phagocytic cells, which transport the virus to the BF for extensive replication in B-cells.

Immunosuppression of very young chickens, less than three weeks of age, is possibly the most important outcome and may not be clinically detectable subclinical. DNA prime-protein boost vaccination enhances protective immunity against infectious bursal disease yumboro in chickens.

Due to partial protection offered by vaccination, especially by nonreplicating constructs subunit and DNA vaccinesthe development of new adjuvants and adjuvant formulations may help to improve the immunogenicity and protection provided by these vaccines.

College of Veterinary Medicine. Bleeding in the breast and thigh muscles may be noted due to impaired blood clotting. Clinically the disease is seen only in chickens older than 3 weeks.

This book is protected by the copyright law. Conventional live attenuated IBDV vaccines categorized as mild, intermediate, or intermediate plus are suitable for mass vaccination and when applied in drinking water can induce robust immunity.

Khatri M, Sharma JM.

A comparison of the sequences of segment A of four infectious bursal disease virus strains and identification of a variable region in VP2. Infectious bursal disease Virus classification Group: Abstract Fulltext Metrics Get Permission. It is suggested that the progression of an infection within a host will determine the ability of a pathogen to transmit to new hosts and to maintain itself in the population, therefore, additional understanding of IBDV pathogenesis and its interactions with the innate immune system is still required to provide the basis for improved prophylactic strategies.


It is economically important to the poultry industry worldwide due to increased susceptibility to other diseases and negative interference with effective vaccination. IBDV genome consists of two segments, A and B, which are enclosed within a nonenveloped icosahedral capsid. Molecular characterization of infectious bursal disease virus IBDV: Smith et al 62 demonstrated higher expression of NK lysin to approximately fold at 4 days post infection dpi compared with virus-free controls suggesting cytotoxic T-cells and NK cells involvement.

[Full text] Infectious bursal disease virus in poultry: current status and future | VMRR

Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide. Accept In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content.

From Wikipedia, the free encyclopedia. Clinical signs of affected birds can include depression and ruffling of feathers, poor or lack of appetite, huddling, unsteady gate, reluctance to rise, and diarrhea sometimes bloody. In other projects Wikimedia Commons Wikispecies. Instructions for submitting birds for gumboto are available on the Necropsy File here. IBD lesions undergo various stages of serous haemorrhagic to severe haemorrhagic inflammation.

Acute infectious bursal disease in poultry: a review.

Clinical Signs Chicks less than three weeks old do not typically show clinical signs of this disease, but their immune systems can nonetheless be adversely affected, and they are not able to fight off the disease.

Chicken bone marrow-derived dendritic cells maturation in response to infectious bursal disease virus.

The IBD virus genome is segmented and is susceptible to genetic mutations through random recombination of its gene segments.